February 05, 2021 Publication

Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication


Multiorgan-on-a-chip (multi-OoC) technology has great potential to metamorphose research in biology and medicine by providing holistic and personalized models for understanding and treating multisystem diseases.

Figure: Various Multiorgan-on-a-Chip Combinations as a Model of Human Physiology and Pathophysiology in Different Biomedical Applications. Figure reproduced from Picollet-D’hahan et.al. , Trends in Biotechnology  https://doi.org/10.1016/j.tibtech.2020.11.014 (CC BY 4.0)

This paper addresses the need for comprehensive multiorgan models with a systemic dimension ,highlights scenarios in which multiorgan models are advantageous and gives an overview of existing multi-OoC platforms. Also the remaining challenges for the realization of multi-OoC platforms and their worldwide adoption are discussed here.

About the authors
The publication was co-written by two Members of the AMBER lab (University of Twente, NL), Séverine Le Gac and Agnieszka Zukowska and two Members of the CEA Grenoble, France, Nathalie Picollet-D’hahan (Organizing Committee EUROoCS 2021 & Chair EUROoCS 2022) and Iris Lemeunier.

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