Nathalie Picollet-D'hahan, Dr.

Commissariat aux Energies Alternatives (CEA)

Organoids, 3D cell culture, Exocrine glands-on-Chip, Cancerogenesis ,

Phone : 0033 4 37 78 67 78

Adress : 17 rue des Martyrs 38054 GRENOBLE - France

Nathalie Picollet-D’hahan (PhD) is in charge of Partnerships & Technology Transfer at the CEA/IRIG Research Institute (Grenoble, France) in the sector of BioHealth. Dr. Picollet-D’hahan graduated in 1997 from Institut Paris-Grignon (INAPG) with a PhD in Biophysics and Pharmacology. After 2 years post-doctoral fellowship in electrophysiology at the CEA Grenoble, she founded a start-up in Multi-Electrode arrays (MEA). In 2002, she obtained a permanent position at the CEA in Grenoble and was in charge of developing ‘cell-on-chip’ devices within the newly created Biochip Lab. During 10 years (2009-2019), she was the head of the Biomics research group focused on 3D organoids engineering (prostate & breast). Capitalizing on this multidisciplinary expertise at the interface between biology and microtechnologies (iRNA-based organoids electroporation, organoids lens-free imaging and chip-based microencapsulation), she focused on OoC applications in the last 6 years, her current research dealing with secretomics-on chip to identify negative effectors of wound healing. She organized international workshops in the field, is involved in several scientific committees, and will chair EUROoCs-2022 in Grenoble. As active partner of the European OoC ORCHID consortium (2017-2020), she co-developed the digital platform & website of EUROoCS, hence contributed to give the EU society its visibility. Involved in recent French initiatives (scientific events, first French OoC directory), she aims at building a French community in OoC. She has co-authored about 25 publications, reviews and book chapters in the field of organoids models and cell-on-chip and is co-inventor of 8 patents.

<strong>Selected publications & patents</strong>

3D polyelectrolyte scaffolds to mimic exocrine glands: a step towards a prostate-on-chip platform. Nathalie Picollet-D’hahan, Axel Tollance, … Xavier Gidrol and Donald K. Martin. <em>The EuroBiotech Journal</em>, 180-195, 4 (2), (<strong>2018</strong>). <a href="https://hal.archives-ouvertes.fr/hal-01978455" rel="noopener">See the publication</a>
Direct transfection of clonal organoids in Matrigel microbeads: a promising approach towards organoid-based genetic screens. Laperrousaz Bastien, …Gidrol Xavier, Picollet-D’hahan Nathalie. <em>Nucleic Acid Res</em>., 1-13 (<strong>2018</strong>). <a href="https://www.ncbi.nlm.nih.gov/pubmed/29394376" rel="noopener">See the publication</a>
Lens-free microscopy for 3D + time acquisitions of 3D cell culture. Anthony Berdeu, Bastien Laperrousaz, ,… Nathalie Picollet-D’hahan & Cédric Allier. <em>Scientific Rep</em>.8, 16135 (<strong>2018</strong>).
Deciphering cell intrinsic properties: A key issue for robust organoids production. Nathalie Picollet-D’hahan, Monika E. Dolega, Delphine Freida, Donald K Martin. Xavier Gidrol. <em>Trends in Biotech</em> 35(11):1035-1048 (<strong>2017</strong>).
A 3D toolbox to enhance the physiological relevance of human tissue models. Nathalie Picollet-D’hahan, Monika E. Dolega, … Xavier Gidrol, Donald K Martin<em>. Trends in Biotech.</em> 34 (9), 757-769 (<strong>2016</strong>).
Controlled 3D culture in Matrigel microbeads to analyze clonal acinar Development. Dolega ME, Abeille F, Picollet-D'hahan N, Gidrol X. <em>Biomaterials</em> 52, 347-357 (<strong>2015</strong>)
Facile bench-top fabrication of enclosed circular microchannels provides 3D confined structure for growth of prostate epithelial cells. Dolega ME, … Gidrol X, Picollet-D’hahan N. <em>PLOS ONE</em> 9:e99416-e99416 (<strong>2014</strong>).
Continuous microcarrier-based cell culture in a benchtop microfluidic bioreactor. Abeille, F., … X. Gidrol, V. Agache, and N. Picollet-D'hahan. <em>Lab on a chip</em>. 14:3510-3518 (<strong>2014</strong>).
Label-free analysis of prostate acini-like 3D structures by lensfree imaging. Dolega ME, Allier C, … Gidrol X, Picollet-D’hahan N. <em>Biosensors & Bioelectronics</em> 49: 176-183 <strong>(2013</strong>).
The modulation of attachment, growth and morphology of cancerous prostate cells by polyelectrolyte nanofilms. Picollet-D'hahan N, … Gidrol X, Martin DK<em>. </em><a href="http://www.ncbi.nlm.nih.gov/pubmed/24060421"><em></em></a><strong>2013</strong>, 34(38):10099-108.
WO patent 194894, 2017.Martin DK, Picollet-D’hahan N. Cell co-culture chip and process for the production thereof.
WO patent 194895, 2017.Martin DK, Picollet-D’hahan N. Method for diagnosing genito-urinary cancers.

<strong>Selected Grants </strong>

CEA Grant “Bottom-Up” DERMONCHIP “Study of cutaneous tropism of oncolytic virus”, 2018-2019, 70K€. Coordinator CEA.
ANR-11-BSV5-009, 2012-2014, “3D polyelectrolyte scaffolds for prostatic cell culture interfaced with microfluidics to identify new biomarkers in cancerous cells secretions”. 480 K€. Co-coordinator CEA and UGA.

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