Nathalie Picollet-D’hahan received her Doctorat in Biophysics and Pharmacology from Institut Paris-Grignon (INAPG) in 1997. After 2 years post-doctoral fellowship in electrophysiology at the CEA Grenoble (1997-2000), she founded a start-up in Multi-Electrode arrays (MEA). In 2002, she obtained a permanent position at the CEA in Grenoble and was involved in the newly created “Biochip” Lab and in charge of developing ‘cell-on-chip’ devices in collaboration with LETI. Since 2009, she is the head of a research group within “Biomics team” focused on 3D prostate organoids, organs-on-chip devices and 3D bioprinted models. She is involved in 3D cell biology and Cancer research and has experience in designing and supervising technological developments for biology. She organized international INSERM workshops on “3D cell culture” in 2014 and on “Organ-on-Chip” in 2018, is authored or co-authored of about 25 publications in the field of 3D organoids culture and cell-on-chip and is co-inventor of 8 patents. She is active member of ORCHID consortium and in charge of conceiving and developing the Digital Platform and the EUROoCS website architecture.
<strong>Selected publications & patents</strong>
3D polyelectrolyte scaffolds to mimic exocrine glands: a step towards a prostate-on-chip platform. Nathalie Picollet-D’hahan, Axel Tollance, … Xavier Gidrol and Donald K. Martin. <em>The EuroBiotech Journal</em>, 180-195, 4 (2), (<strong>2018</strong>). <a href=”https://hal.archives-ouvertes.fr/hal-01978455″ rel=”noopener”>See the publication</a>
Direct transfection of clonal organoids in Matrigel microbeads: a promising approach towards organoid-based genetic screens. Laperrousaz Bastien, …Gidrol Xavier, Picollet-D’hahan Nathalie. <em>Nucleic Acid Res</em>., 1-13 (<strong>2018</strong>). <a href=”https://www.ncbi.nlm.nih.gov/pubmed/29394376″ rel=”noopener”>See the publication</a>
Lens-free microscopy for 3D + time acquisitions of 3D cell culture. Anthony Berdeu, Bastien Laperrousaz, ,… Nathalie Picollet-D’hahan & Cédric Allier. <em>Scientific Rep</em>.8, 16135 (<strong>2018</strong>).
Deciphering cell intrinsic properties: A key issue for robust organoids production. Nathalie Picollet-D’hahan, Monika E. Dolega, Delphine Freida, Donald K Martin. Xavier Gidrol. <em>Trends in Biotech</em> 35(11):1035-1048 (<strong>2017</strong>).
A 3D toolbox to enhance the physiological relevance of human tissue models. Nathalie Picollet-D’hahan, Monika E. Dolega, … Xavier Gidrol, Donald K Martin<em>. Trends in Biotech.</em> 34 (9), 757-769 (<strong>2016</strong>).
Controlled 3D culture in Matrigel microbeads to analyze clonal acinar Development. Dolega ME, Abeille F, Picollet-D’hahan N, Gidrol X. <em>Biomaterials</em> 52, 347-357 (<strong>2015</strong>)
Facile bench-top fabrication of enclosed circular microchannels provides 3D confined structure for growth of prostate epithelial cells. Dolega ME, … Gidrol X, Picollet-D’hahan N. <em>PLOS ONE</em> 9:e99416-e99416 (<strong>2014</strong>).
Continuous microcarrier-based cell culture in a benchtop microfluidic bioreactor. Abeille, F., … X. Gidrol, V. Agache, and N. Picollet-D’hahan. <em>Lab on a chip</em>. 14:3510-3518 (<strong>2014</strong>).
Label-free analysis of prostate acini-like 3D structures by lensfree imaging. Dolega ME, Allier C, … Gidrol X, Picollet-D’hahan N. <em>Biosensors & Bioelectronics</em> 49: 176-183 <strong>(2013</strong>).
The modulation of attachment, growth and morphology of cancerous prostate cells by polyelectrolyte nanofilms. Picollet-D’hahan N, … Gidrol X, Martin DK<em>. </em><a href=”http://www.ncbi.nlm.nih.gov/pubmed/24060421″><em></em></a><strong>2013</strong>, 34(38):10099-108.
WO patent 194894, 2017.Martin DK, Picollet-D’hahan N. Cell co-culture chip and process for the production thereof.
WO patent 194895, 2017.Martin DK, Picollet-D’hahan N. Method for diagnosing genito-urinary cancers.
<strong>Selected Grants </strong>
CEA Grant “Bottom-Up” DERMONCHIP “Study of cutaneous tropism of oncolytic virus”, 2018-2019, 70K€. Coordinator CEA.
ANR-11-BSV5-009, 2012-2014, “3D polyelectrolyte scaffolds for prostatic cell culture interfaced with microfluidics to identify new biomarkers in cancerous cells secretions”. 480 K€. Co-coordinator CEA and UGA.