Christine Mummery, Professor

Leiden University Medical Centre

Human pluripotent stem cells, cardiomyocyte differentiation, cardiovascular diseases, vascular cells,

Phone : +31 71 5269307

Adress : Albinusdreef 2 2333ZA Leiden - Netherlands

Christine Mummery studied physics at the University of Nottingham, UK and has a PhD in Biophysics from the University of London. After positions as postdoc and tenured group leader at the Hubrecht Institute, she became professor at the University Medical Centre Utrecht in 2002. After a sabbatical at the Harvard Stem Cell Institute in 2007, she introduced human iPS cells to the Netherlands. In 2008, she became Professor of Developmental Biology at Leiden University Medical Centre in the Netherlands and head of the Department of Anatomy and Embryology. Her research concerns heart development and the differentiation of pluripotent human stem cells into the cardiac and vascular lineages and using these cells as disease models, for safety pharmacology and drug discovery. Immediate interests are on developing biophysical techniques for characterization and functional analysis of cardiovascular cells from hPSC. In 2015 she became guest professor at the Technical University of Twente to develop organ-on-chip models. She was recently awarded a multimillion grant for this purpose and is awardee of a European Research Council Advanced Grant.

She is a member of the Royal Netherlands Academy of Science (KNAW), and former board member of the International Society of Stem Cell research (ISSCR), the KNAW and the Netherlands Medical Research Council (ZonMW). She was recently awarded the Hugo van de Poelgeest Prize for Animal Alternatives in research. She co-authored a popular book on stem cells “Stem Cells: scientific facts and Fiction” (2nd edition 2014) and is editor in chief of the ISSCR journal Stem Cell Reports. She is also on the editorial boards of Cell Stem Cell, Cardiovascular Research and Stem Cells.

 

Selected publications

Van Laake LW, Passier R, Doevendans PA, Mummery CL (2008) Human embryonic stem cell derived cardiomyocytes and cardiac repair in rodents. Circ. Research 102: 1008-1010. Cit:98
Passier R, van Laake LW, Mummery CL (2008) Stem-cell-based therapy and lessons from the heart. Nature 453(7193):322-9. Cit: 210
Lebrin F, ….. Mummery CL. Thalidomide stimulates vessel maturation and reduces epistaxis in Hereditary Hemorrhagic Telangiectasia patients. Nature Medicine (2010), 16(4):420-8. Cit:33
Bellin M, Marchiotti C, Gage F, Mummery CL. Induced pluripotent stem cells: the new patient? Nature Rev Mol Cell Biol., 2012. 13(11):713-26
Bellin M…., Mummery CL Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome.EMBO J 2013 32:3161-75.
V.V. Orlova, …. C.L. Mummery. Endothelial Cells and Pericytes from human Pluripotent Stem Cells: methods for efficient generation, expansion and examination of functional competence. Nature Protocols 2014 9, 1514-1531 doi:10.1038/nprot.2014.102
Birket MJ, … & Mummery CL. Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells. Nature Biotechnol. 2015 33(9):970-9.
van den Berg, CW, …C.L. Mummery. 2016 Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells. Development 142: 3231-3238
Giacomelli E, Bellin M, Sala L, van Meer BJ, Tertoolen LG, Orlova VV, Mummery CL. Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells. Development. 2017 144(6):1008-1017.
Sala L…..Mummery CL. MUSCLEMOTION: a versatile software tool for measuring contraction of cardiomyocytes in vitro and cardiac muscle in situ. Circ Res. 2018 Feb 2;122(3):e5-e16. doi: 10.1161

 

Research grants (selected)

EU H2020 2016-2020 TECHNOBEART. Huamn PSC-derived cardiobvascualr cells for heart repair.  (450k€).
European Research Council Advanced Grant 2013-2018. Human pluripotent stem cells: the new heart patient. Personal grant/PI (2.5 M€)
Muller Foundation (2014-2019). hiPSC models for vascular disease. PI (750k€).
NWO- ZonMW Gravity Grant (2017-2027) Neth. Organs-on-Chip Initiative (18.8 M€): coordinator
Top-sector grant –TKI (2017-2020) : iPSC cardiac disease models (200k€).

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