Looking to join a consortium for DT-NMBP-23-2020 Next generation organ-on-chip (RIA-LS)
We are Looking to join a consortium for DT-NMBP-23-2020 Next generation organ-on-chip (RIA-LS). We are in the midst of developing organ-on-a-chip models of the male testis. We have access to human tissue from pre-pubertal cancer patients as well as from adults undergoing fertility treatments. Our lab has expertise in microfluidics, electrokinetics, lab-on-a-chip, and lab-on-a-particle. Our partners on this project have extensive experience with in-vitro spermatogenesis. The system could model healthy and diseased testes. The models can then be cultured for many weeks to monitor long-term effects. Our chips could interface with chips simulating other organs, significantly contributing to a multi-organ models. We also aim to be able to monitor the effects of various drugs, chemicals and toxins on the testis and male fertility.
Our lab is the Micro & Nano Fluidics Laboratory at The Technion Israel Institute of Technology. We have have expertise in biorelated applications of microfluidics and electrokinetics. We have projects relating to lab-on-a-chip, lab-on -a-particle and organ-on-a-chip. In addition to our own project relating to the testis, we can also assist in the evaluation of the effects of electrical fields and electrical stimulation on cells, organoids and organ-on-a-chip models.
We have partnered on this project with the lab of Mahmoud Huleihel at Ben Gurion University in Beer Sheva Israel. Their lab specializes in male fertility, in-vitro spermatogenesis and the effects of various cancer treatments on the testis.